Verdict: Lautaro Martinez over 1.5 shots on target

Best Odds: 6/5

Bookmaker: Dachbet

Seeking an immediate Serie A response on Wednesday night, Inter Milan will welcome Fiorentina to the San Siro for what is a heavyweight Italian showdown.

Inter Milan

Starting with the hosts, marking their return from October’s international break with a gritty 1-0 victory away at historic rivals Roma, Inter Milan watched their title dreams take a real dent over the weekend. Eventually falling to a 3-1 loss at the hands of defending Serie A champions Napoli, it has been suggested that new boss Cristian Chivu already has some mounting pressure on his shoulders at the San Siro. However, despite opening Wednesday’s return to Milan sat down in fourth-place, the former Parma manager has seen his squad win each of their other seven appearances across all competitions. Likewise, getting their Champions League adventure underway with three consecutive European victories, Wednesday’s hosts have also continued to shine with their performances on home soil. Heading into October’s fortnight interval with a thumping 4-1 win against Cremonese, Chivu’s camp will certainly be smelling a golden opportunity here.

Inter Milan Team News

Suffering a reported thigh issue against Napoli over the weekend, Inter Milan will be unable to call upon former Arsenal midfielder Henrikh Mkhitaryan on Wednesday night. Likewise, not featuring over the past month, French international Marcus Thuram will once again miss out at the San Siro.

Notching seven goals in his previous eight appearances for club and country, attacking talisman Lautaro Martinez will lead the line here. Completing a loan switch from Manchester City over the summer, Manuel Akanji will start at the heart of Inter’s defence.

Fiorentina

As for the visitors, while Fiorentina might have come flying out of the traps since opening their European adventure, the Viola find themselves at the heart of what has become a public domestic nightmare. Coming under a huge amount of scrutiny since opening up the 2025/26 campaign, Stefano Pioli’s position in Tuscany is growing more unstable by the week. Last seen over the weekend eventually settling for a 2-2 stalemate at home against Bologna, Wednesday’s guests have remarkably failed to muster a single win from any of their first eight Serie A appearances. Putting just four points on the board, Fiorentina travel to the San Siro in midweek sat in the relegation zone. Breaking a strong of unwanted records and failing to find any kind of defensive steel, the former Inter Milan boss will be bracing himself for another monumental challenge here.

Fiorentina Team News

Only managing 26 minutes of Serie A action before suffering yet another long-term knee injury, Fiorentina will be without summer recruit and former Brighton defender Tariq Lamptey on Wednesday night. Likewise, yet to make a single appearance this season, Ivory Coast international Christian Kouame will also miss out here.

Completing a summer switch from Fenerbahce, ex-Inter Milan striker Edin Dzeko could be handed a full recall on his return to the San Siro. Now entering his second campaign in Tuscany, former Manchester United shot-stopper David de Gea will start between the sticks.

Inter Milan vs Fiorentina Key Factors to Consider

• When Inter Milan and Fiorentina last met at the San Siro back on February 10th, Wednesday’s hosts collected a 2-1 victory.
• Despite getting hit with a 3-1 defeat against Napoli over the weekend, Inter Milan have won each of their other seven appearances across all competitions.
• Fiorentina have remarkably failed to win any of their first eight Serie A appearances so far this season (four defeats, four draws).
• Milan have won all of their previous three appearances at the San Siro by an aggregate score of 9-2.
• Inter’s first five showdowns in Milan have produced 19 goals at both ends of the pitch.

Conclusion

Falling to a downbeat 3-1 loss in Naples over the weekend, Inter Milan will certainly be excited to make a return to the San Siro here. Winning all of their other seven appearances across all competitions, Wednesday’s hosts will certainly be smelling a golden opportunity in midweek. Continuing to shine with their performances on home soil, Inter will also meet a Fiorentina squad who find themselves at the heart of a public Serie A crisis. With the Viola remarkably failing to win any of their first eight consecutive domestic showdowns, Inter are rightfully installed as a standout contender.

Verdict: Lautaro Martinez over 1.5 shots on target

Best Odds: 6/5

Bookmaker: Dachbet