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(Picture credit score: KATERYNA KON/SCIENCE PHOTO LIBRARY by way of Getty Photos)
A decades-old drug for urinary tract infections can also work for “brain-eating” amoeba infections, which kill the overwhelming majority of people that contract them, Science magazine reported (opens in new tab).
The drug’s promise was demonstrated in a latest case report, printed in January within the journal Emerging Infectious Diseases (opens in new tab), which describes a 54-year-old man whose mind was infiltrated by the amoeba Balamuthia mandrillaris. The only-celled organism lives in mud, soil and water, and may enter the physique via pores and skin wounds and cuts or via the lungs, when it is inhaled, based on the Centers for Disease Control and Prevention (opens in new tab) (CDC). The amoeba can then infiltrate the bloodstream and journey to the mind, triggering a really uncommon an infection referred to as “granulomatous amebic encephalitis” that kills round 90% of individuals affected.
“The illness would possibly seem delicate at first however can change into extra extreme over weeks to a number of months,” the CDC notes.
The person within the case report initially acquired remedy at a Northern California hospital for an unexplained seizure. Magnetic resonance imaging (MRI) revealed a mass on the left facet of his mind, surrounded by swelling. At this level, the person was transferred to the College of California San Francisco (UCSF) Medical Middle, the place medical doctors took samples of the affected person’s mind tissue and the clear fluid surrounding the mind and spinal twine. This evaluation revealed B. mandrillaris within the man’s mind.
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After consulting the CDC, the affected person’s medical doctors prescribed an aggressive routine of antiparasitic, antibacterial and antifungal medicine. “It is what’s advisable as a result of it was what occurred for use in sufferers who survived,” Dr. Natasha Spottiswoode (opens in new tab), an infectious illness physician-scientist at UCSF and first creator of the case report, instructed Science. Sadly, the remedy triggered extreme unwanted side effects, together with kidney failure, and the affected person wasn’t but amoeba-free.
In quest of one other answer, Spottiswoode dug up a 2018 report, printed within the journal mBio (opens in new tab), wherein UCSF scientists discovered proof that an antibiotic referred to as nitroxoline can kill B. mandrillaris in laboratory settings. The drug is accredited in Europe, however not the U.S., so the medical group sought permission from the Meals and Drug Administration to make use of it; they acquired approval, began the affected person on nitroxoline and noticed speedy enchancment, inside every week.
The affected person was quickly discharged from the hospital and he continued to take nitroxoline at residence, together with different drugs; his clinicians plan to finally discontinue his use of the medicine. Within the meantime, UCSF medical doctors are overseeing the case of a second B. mandrillaris-infected affected person who’s began receiving nitroxoline. They’re seeing comparable enhancements, Science reported.
Learn extra in Science (opens in new tab).
