In just a couple of weeks, we’ll be bidding farewell to 2025. And what a year it has been! Artificial intelligence is being incorporated into more aspects of our lives, weight-loss drugs have expanded in scope, and there have been some real “omg” biotech stories from the fields of gene therapy, IVF, neurotech, and more.   

As always, the team at MIT Technology Review has been putting together our 2026 list of breakthrough technologies. That will be published in the new year (watch this space). In the meantime, my colleague Antonio Regalado has compiled his traditional list of the year’s worst technologies.

I’m inviting you to put your own memory to the test. Just how closely have you been paying attention to the Checkup emails that have been landing in your inbox this year?!

This article first appeared in The Checkup, MIT Technology Review’s weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first, sign up here.