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Analysis Triangle Park, N.C. (January 9, 2023) – Asklepios BioPharmaceutical, Inc. (AskBio), a completely owned and independently operated subsidiary of Bayer AG, introduced right this moment that it has signed a multi-year analysis collaboration and possibility settlement with ReCode Therapeutics. Beneath this settlement, the businesses will work collectively to doubtlessly uncover precision genetic medicines by the event of a novel platform for full gene insertion by single vector supply of gene modifying and DNA cargoes. This represents one other step ahead for AskBio in creating its gene modifying and different nonviral supply applied sciences and experience.
“The collaboration pairs AskBio’s experience in artificial DNA and CRISPR functions with ReCode’s novel SORT LNP supply expertise to doubtlessly uncover new genetic medicines,” stated AskBio’s Chief Government Officer Sheila Mikhail. “By means of this collaboration, we now have a chance to advance AskBio’s gene modifying and nonviral supply efforts, which help and align with our dedication to function an industry-leading engine of gene remedy innovation.”
Beneath the settlement, AskBio will mix its artificial DNA and gene modifying nucleases with ReCode’s selective organ concentrating on (SORT) lipid nanoparticle (LNP) expertise to doubtlessly create an all-in-one answer that permits full gene insertion by delivering with precision each the gene modifying software and DNA as blended cargo in a single LNP to desired targets. This collaboration may prolong the attain of gene modifying for liver and lung illness targets.
“AskBio’s pioneering gene modifying expertise is a strong complement to our modular SORT LNP genetic medicines platform, which allows the exact supply of all kinds of genetic cargoes to particular organs and cells, together with giant, complicated genetic cargoes and blended payloads,” stated Shehnaaz Suliman, M.D., MBA, M.Phil., Chief Government Officer of ReCode Therapeutics. “We’re excited to mix these distinctive platforms to develop next-generation genetic therapies with the potential to rework the lives of sufferers affected by a variety of debilitating genetic illnesses.”
In June 2022, ReCode introduced the closing of a $200 million Collection B extension financing spherical, co-led by Leaps by Bayer, the influence funding unit of Bayer AG, to additional strengthen Leaps by Bayer’s innovation portfolio in gene therapies. The funds raised are getting used to advance the event of ReCode’s platform and pipeline to selectively ship genetic medicines to focus on organ and cell sorts in a predictable and programmable trend.
About AskBio
Asklepios BioPharmaceutical, Inc. (AskBio), a completely owned and independently operated subsidiary of Bayer AG, is a totally built-in gene remedy firm devoted to creating life-saving medicines and altering lives. The corporate maintains a portfolio of scientific applications throughout a variety of neuromuscular, central nervous system, cardiovascular and metabolic illness indications with a clinical-stage pipeline that features therapeutics for Pompe illness, Parkinson’s illness and congestive coronary heart failure. AskBio’s gene remedy platform contains Pro10™, an industry-leading proprietary cell line manufacturing course of, and an intensive capsid and promoter library. With international headquarters in Analysis Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the corporate has generated a whole bunch of proprietary capsids and promoters, a number of of which have entered scientific testing. Based in 2001 and an early innovator within the gene remedy area, the corporate holds greater than 750 patents in areas resembling AAV manufacturing and chimeric and self-complementary capsids. Study extra at www.askbio.com or comply with us on LinkedIn.
About ReCode Therapeutics
ReCode Therapeutics is a genetic medicines firm utilizing superior supply to energy the subsequent wave of messenger RNA (mRNA) and gene correction therapeutics. ReCode’s selective organ concentrating on (SORT) lipid nanoparticle (LNP) platform is a next-generation, genetic medicines expertise that permits exact supply to focus on organs and cells past the liver. The SORT LNP platform is the inspiration for ReCode’s pipeline of disease-modifying mRNA and gene correction therapeutics. ReCode’s lead applications are targeted on major ciliary dyskinesia and cystic fibrosis. ReCode is leveraging its SORT LNP platform and nucleic acid applied sciences to develop its pipeline with therapeutics that use mRNA-mediated substitute and gene correction in goal organs with precision concentrating on of disease-relevant cells. In 2022, ReCode was named amongst Fierce Biotech’s “Fierce 15” as probably the most promising early-stage biotechnology corporations within the {industry}, and was described by Nature as one of many “Seven Applied sciences to Watch in 2022” for its SORT LNP platform. For extra info, go to www.recodetx.com and comply with us on Twitter @ReCodeTx and on LinkedIn.
About Bayer
Bayer is a world enterprise with core competencies within the life science fields of well being care and vitamin. Its services are designed to assist individuals and the planet thrive by supporting efforts to grasp the main challenges introduced by a rising and growing older international inhabitants. Bayer is dedicated to driving sustainable improvement and producing a optimistic influence with its companies. On the identical time, the Group goals to extend its incomes energy and create worth by innovation and development. The Bayer model stands for belief, reliability and high quality all through the world. In fiscal 2020, the Group employed round 100,000 individuals and had gross sales of 41.4 billion euros. R&D bills, earlier than particular gadgets, amounted to 4.9 billion euros. For extra info, go to www.bayer.com.
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Media Contact:
Phil McNamara
Vice President, Company Communications, AskBio
E: pmcnamara@askbio.com
T: +1 984.389.1797
